In this section you can check out Belarusian author’s publications in foreign periodicals which are accessible in RSML. To order a full text, use Electronic medical library or the Electronic document delivery service.
| Диагностическое иммунофенотипирование острых лейкозов. Рекомендации российско-белорусской кооперативной группы по диагностике острых лейкозов у детей / А. М. Попов, Т. Ю. Вержбицкая, Л. В. Мовчан (Минск), И. А. Демина, Е. В. Михайлова, А. А. Семченкова, Ж. В. Пермикин, Т. В. Шман (Минск), А. И. Карачунский, Г. А. Новичкова // Вопросы гематологии / онкологии и иммунопатологии в педиатрии [Москва]. – 2023. – Т. 22, № 1. – С. 165–177. – Библиогр.: 55 назв.(Flow cytometry in acute leukemia diagnostics. Guidelines of Russian-Belarusian multicenter group for pediatric leukemia studies) |
Flow cytometry is one of the key technologies for acute leukemia (AL) diagnostics. Nevertheless, lack of technological standards hampers implementation of immunophenotyping data in treatment protocols. Earlier our group published the acute lymphoblastic leukemia diagnostic standards. In this paper, we present the updated guidelines for initial immunophenotyping of ALs. This wellharmonized approach includes recommendations for monoclonal antibodies choice, sample preparation, cytometer setup, data analysis and interpretation as well as for the report writing. These guidelines allows application of diagnostic flow cytometric studies in all types of AL. |
| Взаимоотношения корней моляров с нижней стенкой верхнечелюстной пазухи / Р. С. Мехтиев (Минск), Ю. М. Мельниченко (Минск), С. Л. Кабак (Минск), Н. А. Саврасова (Минск), В. В. Заточная (Минск) // Стоматология [Москва]. – 2023. – Т. 102, № 1. – С. 52–59. – Библиогр.: 24 назв.(Relationships between the inferior wall of maxillary sinus and the roots of the maxillary molars) |
Objective: The aim of the study is to evaluate the position of the roots of the first and second upper molars relative to the bottom of the maxillary sinus (maxillary sinus) according to cone-beam computed tomography (CBCT). Material and metods: The CBCT scans of 150 patients (69 men and 81 women) from the database of the X-ray department of the 11th City Clinical Hospital of Minsk who applied for dental care were studied. There are 4 variants of vertical relationships between the roots of the teeth and the lower wall of the maxillary sinus. At the contact of the molar roots and the bottom of the HPV, 3 variants of the horizontal relationship between the roots of the teeth and the bottom of the maxillary sinus in the frontal plane were identified. Results: The root apices of the maxillary molars can be located below the level of the MSF (type 0; 16.69%), contact with MSF (types 1-2; 72%) or protrude into the sinus cavity (type 3; 11.31%) at a distance of up to 6.49 mm. The roots of the second maxillary molar showed greater proximity to the MSF than the first molar roots and more often protruded into the maxillary sinus. The most common type of horizontal relationship between the molar roots and the MSF, in which the lowest point of the MSF was located centrally between buccal and palatal roots. It was found that the proximity between the roots and the MSF correlates with maxillary sinus vertical dimension. This parameter was significantly greater in type 3 when the roots protruded into the maxillary sinus than in type 0, when there was no contact between the MSF and the root apices of the molar teeth. Conclusion: Significant individual variability in the anatomical relationships between the roots of the maxillary molars and the MSF indicates the need for the mandatory appointment of cone-beam computed tomography in preoperative planning for the extraction of these teeth and/or their endodontic treatment. |
| Лечение и реабилитация больных с неврологическими нарушениями после перенесенного COVID-19. Резолюция Международного форума экспертов / О. С. Левин, В. В. Ващилин (Минск), С. Пикия, Д. Р. Хасанова, С. Т. Туруспекова, А. Н. Боголепова, А. А. Шмонин, М. Н. Мальцева, И. А. Вознюк, С. Н. Янишевский, Д. К. Гусейнов, Ю. В. Каракулова, Ф. Х. Обидов // Журнал неврологии и психиатрии им. С. С. Корсакова [Москва]. – 2023. – Т. 123, № 2. – С. 44–51. – Библиогр.: 59 назв.(Current approaches in the treatment and rehabilitation of patients with neurological diseases after COVID-19. Resolution of the International Experts Forum) |
The aim of the study is to evaluate the position of the roots of the first and second upper molars relative to the bottom of the maxillary sinus (maxillary sinus) according to cone-beam computed tomography (CBCT). Material and metods: The CBCT scans of 150 patients (69 men and 81 women) from the database of the X-ray department of the 11th City Clinical Hospital of Minsk who applied for dental care were studied. There are 4 variants of vertical relationships between the roots of the teeth and the lower wall of the maxillary sinus. At the contact of the molar roots and the bottom of the HPV, 3 variants of the horizontal relationship between the roots of the teeth and the bottom of the maxillary sinus in the frontal plane were identified. Results: The root apices of the maxillary molars can be located below the level of the MSF (type 0; 16.69%), contact with MSF (types 1-2; 72%) or protrude into the sinus cavity (type 3; 11.31%) at a distance of up to 6.49 mm. The roots of the second maxillary molar showed greater proximity to the MSF than the first molar roots and more often protruded into the maxillary sinus. The most common type of horizontal relationship between the molar roots and the MSF, in which the lowest point of the MSF was located centrally between buccal and palatal roots. It was found that the proximity between the roots and the MSF correlates with maxillary sinus vertical dimension. This parameter was significantly greater in type 3 when the roots protruded into the maxillary sinus than in type 0, when there was no contact between the MSF and the root apices of the molar teeth. Conclusion: Significant individual variability in the anatomical relationships between the roots of the maxillary molars and the MSF indicates the need for the mandatory appointment of cone-beam computed tomography in preoperative planning for the extraction of these teeth and/or their endodontic treatment. |
| Диагностические критерии гипоплазии верхнечелюстной пазухи по данным конусно-лучевой компьютерной томографии / Ю. М. Мельниченко (Минск), С. Л. Кабак (Минск), Н. А. Саврасова (Минск), Н. В. Журавлева (Минск) // Вестник оториноларингологии [Москва]. – 2023. – Т. 88, № 1. – С. 44–49. – Библиогр.: 25 назв.(Diagnostic criteria of maxillary sinus hypoplasia using cone-beam computed tomography) |
Objective: To evaluate the diagnostic significance of X-ray criteria of maxillary sinus hypoplasia. Material and methods: Cone-beam computed tomography (CBCT) data of 553 patients (1006 maxillary sinuses) with dental and ENT pathology from Minsk outpatient clinics, were studied. The morphometric parameters of 23 maxillary sinuses with radiological signs of hypoplasia, as well as orbits on the affected side, were analyzed. The maximum linear dimensions were measured using the tools of the CBCT viewer. The convolutional neural network technology was applied for maxillary sinus semi-automatic segmentation. Results: The reliable radiological signs of hypoplasia of the maxillary sinus are a two-fold decrease in its height and/or width relative to the corresponding dimensions of the orbit, a high level of location of the inferior wall of the sinus, displacement of its medial wall to the lateral side, anterolateral wall asymmetry in association with unilateral hypoplasia, as well as lateralization of the uncinate process and ethmoid infundibulum with narrowing of ostial passage. Conclusion: In unilateral hypoplasia, the volume of the sinus is reduced by 31-58% compared to the contralateral side. |
| Показатели психического здоровья населения Республики Беларусь / А. В. Ходжаев (Минск), Т. С. Голубева (Минск), Ю. М. Каминская (Минск), Ю. А. Чумаков (Минск), Л. И. Сафронова (Минск), А. В. Копытов (Минск) // Психическое здоровье [Москва]. – 2023. – Т. 18, № 1. – С. 3–13. – Библиогр.: 6 назв.(Indicators of mental health of the population of the Republic of Belarus ) |
Objective. To analyze the morbidity and disability rates of mental disorders in the Republic of Belarus over a ten-year period (2012-2021), changes in the nosological structure of mental disorders morbidity since 1994, the contribution of the main nosological forms to the structure of mental disorders morbidity on average for 2016-2021. Methods. Analysis of state statistical reporting forms (Form 1 – psychiatry (Ministry of Health)) and data provided by the regions of the republic. Results. In the period 2012-2021, the primary morbidity rate of mental disorders tended to decrease. The primary incidence of mental disorders throughout the study period was higher among child, female and urban population than among adult, male and rural population, respectively. The rate of overall incidence of mental disorders also decreased. The overall incidence of mental disorders in the child population was higher than the overall incidence in adults in 2012, and these rates are nearly equal in 2020 and 2021. Total morbidity among men and women did not differ significantly. In rural areas it was higher than among urban residents. In the nosological structure of the general and primary morbidity of mental disorders there was an increase in the specific weight of non-psychotic mental disorders, a decrease in the specific weight of patients with schizophrenia, schizotypal, schizoaffective disorders and mental retardation. In recent years, the main contribution to the total and primary morbidity was made by: organic, including symptomatic, mental disorders (rank I), neurotic, stress-related and somatoform disorders (rank II), as well as disorders of psychological development, emotional disorders and behavioral disorders beginning usually in childhood and adolescence (rank III). Between 2012 and 2021, there was an increase in the rate of primary disability and total disability: the rate of increase in primary disability was 72.2% and the rate of increase in total disability was 29.3%. Conclusion. Over the period 2012-2021 the state of mental health of the population of the Republic of Belarus was characterized by a decrease in the primary and general morbidity of mental and behavioral disorders against the background of an increase in primary disability rates and the number of the total number of persons with disabilities due to mental disorders. |
| Оценка эффективности Ремаксола у пациентов с COVID-19 на противовирусной терапии / А. А. Шульдяков, Е. П. Ляпина, А. Н. Смагина, О. Б. Лиско, А. Л. Коваленко, Е. И. Козорез (Гомель) // Инфекционные болезни [Москва]. – 2023. – Т. 21, № 1. – С. 41–48. – Библиогр.: 27 назв.(Metabolic support of antiviral therapy in patients with COVID-19) |
Remaxol was evaluated as a means of hepatotropic support for patients with COVID-19 receiving antiviral therapy. Patients were observed in two groups of 30 people each and received intravenous infusions of Remaxol (400.0 ml) or “active placebo” (400.0 ml. 0.9% sodium chloride) for 10 days. In these groups of patients, an analysis was made of the dynamics of clinical parameters and laboratory tests that characterize the functionality of the liver. The results of the analysis made it possible to state that the use of the corrector of cellular and energy metabolism metabolism Remaxol as a hepatoprotector in complex therapy contributes to favorable clinical dynamics, stabilization of biochemical parameters of liver function and allows completing the course of etiotropic therapy in all patients. Good tolerability of the drug “Remaxol” and the absence of pronounced side effects were noted. The course of Remaxol made it possible to carry out therapy with antiviral agents without dose adjustment and duration of treatment. |
| Нормативно-правовое сопровождение наркологической помощи в Республике Беларусь: обзор национальных актов законодательства / А. В. Ходжаев (Минск), Ю. М. Каминская (Минск), С. И. Осипчик (Минск), С. А. Гуляев (Минск) // Наркология [Москва]. – 2023. – Т. 22, № 1. – С. 13–22. – Библиогр.: 31 назв.(Normative-legal support of narcological care in the Republic of Belarus: a review of national legislative acts) |
In the Republic of Belarus, drug treatment is provided to the population on the basis of national legislative acts of the Constitution of the Republic of Belarus, laws, resolutions of the Council of Ministers of the Republic of Belarus, normative legal acts of the Ministry of Health, etc., which take into account the positions of international documents concerning the provision of this profile of specialized medical care. The article presents an overview of normative legal acts that regulate the provision of drug treatment in the Republic of Belarus. |
| Применение метода психотерапии лиц с синдромом зависимости от алкоголя, склонных к агрессивному поведению / И. В. Григорьева (Минск), А. В. Ходжаев (Минск), Ю. М. Каминская (Минск), С. С. Кононов (Минск) // Наркология [Москва]. – 2023. – Т. 22, № 2. – С. 52–64. – Библиогр.: 18 назв.(Application of psychotherapy method for persons with alcohol dependence syndrome prone to aggressive behavior) |
The article considers and proposes the author’s method of psychotherapy of persons with alcohol dependence syndrome prone to aggressive behavior. The approach is based on an integrated model of psychotherapeutic assistance to alcohol-dependent persons, aimed at overcoming anosognosia, reducing the level of anxiety, overcoming psychological defenses, breaking the patterns of dependent and aggressive behavior, forming positive attitudes and skills of prosocial interaction. Application of the method allows to increase the efficiency of psychosocial rehabilitation in patients with alcohol dependence, to form stable remissions of high quality, to provide stability of the results in the distant period. Methods. The study sample included 198 men with alcohol dependence syndrome (F10.2) aged from 21 to 60 years, mean age 40.7+8.9 years, alcohol intake averaged 13.5 years. The results were approved by the protocol of the ethics meeting No. 2 of 13.08.2019 of the ethics committee of the State Institution “Republican Scientific and Practical Center for Mental Health”. The purpose of the method of psychotherapy of persons with alcohol dependence syndrome prone to aggressive behavior was to overcome addictive, aggressive and illegal behavior in persons with alcohol dependence syndrome.The Method of Psychotherapy for Persons with Alcohol Dependence Syndrome Prone to Aggressive Behavior (MPAB) consists of 12 psychotherapeutic modules, which are implemented in stages, designed for 36 sessions, from 60 to 120 minutes each. Classes are held on average twice a week. The main form of work is group psychotherapy, groups of 8-10 people. The forms of work include theoretical and practical parts. At the end of each module a self-report sheet is drawn up, which is filled out by the patient and allows to evaluate the effectiveness of the work done. To test the method of psychotherapy of persons with alcohol dependence syndrome prone to aggressive behavior, the following techniques were used: “Bass-Perry aggression propensity questionnaire”; Test-questionnaire ‘Study of volitional self-regulation’; Scale of readiness to change behavior and desire for treatment ‘SOCRATES’; Questionnaire for the study of stages of psychotherapy ‘URICA’. The I main group was formed by the method of purposeful selection and included patients with alcohol dependence syndrome in the penitentiary system, aged from 21 to 60 years, who underwent psychotherapy (100 patients); the II comparison group included patients with alcohol dependence syndrome in the penitentiary system, aged from 21 to 60 years, undergoing a standard program of medical and social rehabilitation (98 patients). Statistical analysis of the data was performed using SPSS 19.0.
To assess differences between two independent samples, the Mann-Whitney U-test was used to compare two independent samples and the Wilcoxon T-test to compare two dependent samples with each other (before and after psychotherapy) in terms of the level of trait expression. Results. The obtained results of the catamnestic evaluation, carried out after six months in the persons of the main group, who underwent MPAB, in comparison with the indicators of the comparison group showed the presence of statistically significant differences in all the studied indicators: a decrease in the level of the general index of aggression; an increase in the level of development of volitional self-regulation; an increase in the willingness to change behavior and desire for treatment and the choice of the stage of psychotherapy at the level of preservation of the obtained results (p<0,01). New skills obtained in the process of MPAB in alcohol-dependent persons confirmed the correctness of the chosen integrative approach and the effectiveness of psychotherapeutic influences in minimizing aggressive and illegal behavior of persons with alcohol dependence in the short-term and subsequent remote period. |
| Отдаленные результаты применения локальной терапии метастазов меланомы хориоидеи в печени / И. Ю. Жерко (Минск), П. Д. Демешко (Минск), Л. В. Науменко (Минск), С. А. Красный (Минск) // Онкология. Журнал имени П. А. Герцена [Москва]. – 2023. – Т. 12, № 2. – С. 5–10. – Библиогр.: 28 назв.(Long-term results of local therapy for choroidal melanoma liver metastases) |
To evaluate the efficacy of treatment of metastatic melanoma of chorioidea in a retrospective single-institution study. Material and methods. The data of 92 patients diagnosed with chorioid melanoma and systemic progression of the disease served as the material for the analysis. Special methods of treatment of metastatic melanoma of chorioidea included chemotherapy, immunotherapy with interleukin-2. Therapy of liver metastases included chemoembolization of the hepatic artery and surgical removal of lesions. The 1-, 3-, 5-, and 10-year adjusted survival rates of patients were analyzed, as well as the influence of T category, type of treatment, and presence of liver metastases on survival rates. Results. Among all patients included in the study, isolated liver lesions were observed in 47.8% of cases. At the same time local therapy was applied in 10 cases. There was a statistically significant reduction in the risk of death with local therapy for liver metastases (OR 0.19, 95% CI 0.04-0.8; p=0.03). Median adjusted survival with either local therapy for liver metastases was 26 months (95% CI 15.0-52.0), with special treatment without local therapy was 11 months (95% CI 7.2-14.7; p=0.02). Conclusion. Multivariate regression analysis revealed a statistically significant reduction in the risk of death from metastatic chorioideal melanoma when localized treatments for liver metastases were used (OR 0.19, 95% CI 0.04-0.8; p=0.03). |
| Пренатальная диагностика несовершенного остеогенеза у беременной женщины с низким ростом / Н. Н. Медведева (Минск), А. А. Лазаревич (Минск), А. А. Гусина (Минск), А. И. Кульпанович (Минск), О. В. Прибушеня (Минск) // Пренатальная диагностика [Москва]. – 2023. – Т. 22, № 1. – С. 60–66. – Библиогр.: 14 назв..(Prenatal diagnosis of osteogenesis imperfecta in a pregnant woman with short stature) |
We present a case of osteogenesis imperfecta (OI) type 2B. The clinical diagnosis was established in a 38-year-old female patient who consulted a geneticist to determine the prognosis of her offspring after two terminations of pregnancy for medical and genetic reasons and one spontaneous miscarriage. Prenatal diagnosis was performed and molecular genetic confirmation of the diagnosis was obtained. The article discusses the methods of diagnostics, clinical forms, peculiarities of the course of the disease in the presence of the same mutations in patients, modern possibilities of therapy. The problems arising during pregnancy and delivery in the presence of the diagnosis of OI in the mother or fetus, as well as the difficulties arising in medical and genetic counseling of patients with OI and possible approaches to overcoming them are discussed. |
| Новикова, И. В. Дисплазия височных и затылочных долей у плодов с танатофорной дисплазией / И. В. Новикова (Минск), С. Н. Пашук (Минск), Н. А. Венчикова (Минск) // Пренатальная диагностика [Москва]. – 2023. – Т. 22, № 1. – С. 53–59. – Библиогр.: 20 назв.(Dysplasia of temporal and occipital lobes in fetuses with thanatophoric dysplasia ) |
Two cases of thanatophoric dysplasia (TD) in fetuses aborted in the 2nd trimester of pregnancy after prenatal diagnosis of TD are described. In the first case, type 1 TD was confirmed by pathologoanatomic examination, and in the second case, type 2 TD was diagnosed. Molecular genetic study in a fetus with TD type 2 in the FGFR3 gene revealed mutation c. 1948A>G (p.Lys650Glu). In both cases, neuropathologic examination revealed a common pathognomonic feature, temporal and occipital lobe dysplasia. |
| Сычик, С. И. О результатах согласованной государственной политики в области борьбы с табакокурением среди молодежи / С. И. Сычик (Минск), Т. Н. Пронина (Минск) // Гигиена и санитария [Москва]. – 2023. – Т. 102, № 2. – С. 154–161. – Библиогр.: 6 назв.(On the results of the coordinated state policy in the field of tobacco control among young people) |
Trend analysis of tobacco consumption rates is important for assessing the effectiveness of national tobacco control measures in Belarus. Materials and methods. The study aims to monitor tobacco smoking among adolescents in Belarus by three repeat national cross sectional surveys conducted before and after introduction the regulatory act tobacco measures entered into force. Prevalence of smoking tobacco, cigarettes, electronic cigarettes and other aspects related to smoking among 13–15 years adolescents were estimated from the 2004, 2015 and 2021 Global Youth Tobacco (GYT) Surveys (n = 4523, n = 2992, n = 3493 respectively) conducted in Belarus. Results. The data evidenced a successful anti-tobacco policy and an improvement in the tobacco consumption and tobacco consumption by 13–15 years adolescents, expressed in reduction of many indicators. Prevalence of current cigarettes smokers significantly decreased from 26.5% in 2004 to 4.7% in 2021. Despite of current reduction of various types of tobacco smokers current GYTS data revealed that electronic cigarettes are extremely popular among adolescents – around 15%. The number of smokeless tobacco users significantly increased by 3 times. Limitations. In order to study the tobacco consumption levels and other aspects related to smoking a survey of 11,000 adolescent students in 2004, 2015 and 2021 was conducted among schoolchildren (13–15 years old), which is a sufficient reference sample. Conclusions. Thus, the identified positive trends in tobacco smoking (5-fold reduction in the number of cigarette smokers, decrease in susceptibility to smoking, reducing the number of tobacco products smokers and decrease the number of ever tobacco smokers and ever cigarette smokers, decreasing the number of frequent cigarette smokers) indicated the effectiveness of a complex multidisciplinary anti-tobacco measures in Belarus. New challenges and negative trends were determined. Amount of electronic cigarettes users were significantly greater than current cigarette smokers’ amount. Moreover, prevalence of users of smokeless tobacco products is getting increased. Despite of extensive legislative framework for the tobacco control there remains substantial potential to strengthen them. |
| Стома, И. О. Вакцинация как стратегия преодоления антимикробной резистентности: свежий взгляд на известную проблему / И. О. Стома (Гомель) // Журнал инфектологии [Санкт-Петербург]. – 2023. – Т. 15, № 1. – С. 5–15. – Библиогр.: 57 назв.(Vaccination as a strategy to overcome antimicrobial resistance: a fresh look on a well-known problem) |
The issue of antimicrobial resistance continues to be on the first page of the global agenda. The system of factors influencing the growth of antibiotic resistance in bacteria comes from various fields (medicine, veterinary medicine, agriculture and the environment), what requires a One Health approach. Vaccination as one of the most important tools against antimicrobial resistance is considered in detail in this review. Vaccine-induced direct and indirect mechanisms for overcoming antimicrobial resistance are presented, as well as the current evidence base and perspectives for expanding the use of vaccines in the context of this problem. Increased vaccination against both known bacterial pathogens (Pneumococcus, Haemophilus influenza type b, typhoid fever) and viral infections (influenza, rotavirus) would reduce the burden of antibiotic-resistant infections, and thus preserve effective options for treatment and saving lives. |
| Предикторы длительности стационарного лечения острой фазы инфекционного процесса, вызванного COVID-19 / Е. С. Панько (Брест), С. В. Жаворонок (Минск), А. М. Соловчук (Брест), С. С. Панько (Брест), С. В. Панько (Брест) // Журнал инфектологии [Санкт-Петербург]. – 2023. – Т. 15, № 1. – С. 86–92. – Библиогр.: 28 назв.(Predictors of length of hospital stay in patients with acute COVID-19) |
The aim of the study was to identify the predictors of length of hospital stay in patients with acute COVID-19, based on the pathophysiological particularities of SARS. Materials and methods: The study was conducted from December 2020 to May 2021 on 103 randomized patients (59 men, mean age 62±13 years, body mass index 30.3±5.5 kg/m2) with moderate to severe acute COVID-19 infection who were hospitalized for emergency non-invasive oxygen therapy. Log-regression models were used to assess the suitability of some functional spirometric variables and/or SpO2/FiO2 surrogate oxygenation index to predict the duration of inpatient treatment from the day of the examination (≤ 7 vs. > 7 days). Results: The analysis of the receiver operating characteristic curves showed that the relative indicator of the “ventilatory reserve” (the ratio of maximum voluntary ventilation to minute ventilation at rest, VR= MVV / MV) has sufficient sensitivity (82%), specificity (69%) and the area under the curve (AUC=0.7), although the SpO2/FiO2 ratio has a better predictive capacity (78%, 84% and 0.8 accordingly). The model combining these two integral indicators of gas exchange and the respiratory muscles reserve showed the best sensitivity (89%), specificity (84%) and area under the curve (0.9). Conclusion: The proposed model for determining of the hypoxia vector by assessing the severity of ventilation-perfusion dissociation with indicators of oxygenation and ventilation showed that the MVV/MV ratio and SpO2/FiO2 ratio can be used alone and especially in combination, as effective outcome predictors of the acute phase of the infectious process caused by SARS-CoV-2. |
| Устойчивость к противомикробным препаратам пищевых изолятов Salmonella enterica на территории Республики Беларусь / Н. Г. Куликова, А. В. Чернышков, Ю. В. Михайлова, А. Л. Зенькович (Минск), Д. А. Довнар (Минск), А. М. Марейко (Минск), Л. А. Битюмина, А. А. Шеленков, А. Е.Егорова, С. С. Саенко, И. Н. Манзенюк // Журнал микробиологии, эпидемиологии и иммунобиологии [Москва]. – 2023. – Т. 100, № 2. – С. 153–167. – Библиогр.: 34 назв.(Antimicrobial resistance in foodborne Salmonellaenterica isolates in the Republic of Belarus) |
Antimicrobial resistance is a global public health concern. Salmonella spp., which can be transmitted to humans through contaminated food, are among the most important foodborne pathogens worldwide. Materials and methods.The antimicrobial resistance of 358 bacterial isolates collected from food and water in the Republic of Belarus (Belarus) in 2018–2021 was studied by analyzing phenotypic and genotypic characteristics of antibiotic bacterial resistance. MALDI-TOF mass spectrometry was used to classify and identify bacteria. Phenotypic antimicrobial susceptibility of bacteria was measured by the minimum inhibitory concentration method using a Sensititre automated bacteriological analyzer and the disk diffusion test for 45 antimicrobial agents. Antimicrobial resistance genes in multidrug-resistant Salmonella isolates were identified by whole-genome sequencing. Results. The in vitro testing of phenotypic bacterial susceptibility showed high susceptibility to fluoroquinolones (97.2%), third-generation cephalosporins (93.9%), carbapenems (98.0%), ampicillin (81.8%), aminoglycosides (97.5%), tetracyclines (87.5%), chloramphenicol (93.8%), trimethoprim/sulfamethoxazole (co-trimoxazole) (95.3%) and colistin (85.2%). It was found that the antibiotic resistance mechanism in S. enterica was associated with the presence of genes blaTEM-1B (82%), blaTEM-1C (7.7%), blaSHV-12 (2.6%), blaDHA-1 (2.6%), blaCMY-2 (7.7%), qnrB2 (9.1%), qnrB4 (9.1%), qnrB5 (9.1%), qnrB19 (72.7%), aac(6’)-Ib-cr (9.1%), aac(6’)-Iaa(100%), aadA1 (13.2%), aadA2 (8.8%), tetB (74.3%), tetA (25.7%), tetM (2.9%), tetD (28.6%), mcr-9 (1.5%).Conclusion.All the bacterial isolates were phenotypically susceptible to first-line antibiotics used in treatment of salmonellosis: fluoroquinolones and third-generation cephalosporins. The whole-genome sequencing of multidrug-resistant Salmonella isolates (19.0%) detected resistance genes for 9 groups of antibiotics: aminoglycosides (100%), beta-lactams (57.4%), fluoroquinolones (16.2%), tetracyclines (51.5%), macrolides (1.5%), phenicols (30.4%), trimethoprim (13.0%), sulfonamides (47.8%) and colistin (1.4%). Thus, epidemiological surveillance of the Salmonella spread through the food chain is of critical importance for the monitoring of antimicrobial resistance among foodborne Salmonella. |
| Влияние повидон-йода на чувствительность клинических изолятов Klebsiella pneumoniae к антибиотикам / Ж. Ф. Циркунова (Минск), А. А. Емельянова (Минск), Е. И. Гудкова (Минск), Г. А. Скороход (Минск) // Журнал микробиологии, эпидемиологии и иммунобиологии [Москва]. – 2023. – Т. 100, № 2. – С. 209–218. – Библиогр.: 25 назв.(Influence of povidone-yodine on the sensitivity of clinical isolates of Klebsiella pneumoniae to antibiotics) |
Cross-resistance of microorganisms to antibiotics against the background of the use of biocides in subinhibitory concentrations is an urgent problem of modern health care. The aim of the work is to study the effect of povidone-iodine on the sensitivity of clinical isolates of Klebsiella pneumoniae to antibiotics. Materials and methods. The work analyzed the effect of povidone-iodine at subinhibitory concentrations on changes in the sensitivity of clinical isolates of K. pneumoniae (n = 9) to antibacterial agents (n = 15). Adaptation of bacteria to povidone-iodine was carried out using periodic cultivation of microorganisms, which was carried out in 96-well culture plates for suspension cultures (non-treated) without stirring. The sensitivity of bacteria to antibiotics was assessed using an automatic analyzer “Vitek2Compact” (“BioMerieux”) using AST-204 charts. Results. During the adaptation of clinical isolates of K. pneumoniae to povidone-iodine, an increase in the sensitivity of bacteria to antibiotics was shown. The minimum inhibitory concentrations (MIC) of 11 antibacterial agents in relation to the studied cultures decreased by an average of 2.35–23.2 times compared with the control values. Under the experimental conditions, the sensitivity of the studied cultures increased to amoxicillin/ clavulanic acid by ≥ 2 – ≥ 8 times, piperacillin/tazobactam — by ≥ 2 – ≥ 32 times, ceftazidime — by 4 –≥ 16 times, ami-kacin — 2 – ≥ 16 times, ertapenem — 2.0–8.0 times, meropinem — 2–8 times, cefepim —≥ 4 – ≥ 64 times, ciprofloxacin — 4 – ≥ 16 times, gentamicin — 2 – ≥ 8 times, norfloxacin — 2–8 times, nitrofurantoin — 2–4 times. An increase in the level of sensitivity to antibiotics was found in 50–100% of the studied clinical bacterial isolates. A similar effect has not been established for ampicillin, cefotaxime, imipenem, and trimethoprim/sulfamethoxazole. It should be noted that under the conditions of the experiment, intraspecific heterogeneity of clinical isolates of K. pneumoniae was revealed in terms of the level of acquired sensitivity to antibacterial agents. Discussion. Our results are not described in the scientific literature and require further study and explanation. |
| Эффективность курсового применения пальмитоилэтаноламида и трансплантации мезенхимальных стволовых клеток при экспериментальной периферической нейропатической боли / А.-М. В. Ерофеева (Минск), О. А. Антипова (Минск), И. П. Жаворонок (Минск), С. Н. Рябцева (Минск), А. Ю. Молчанова (Минск) // Патофизиологическая физиология и экспериментальная терапия [Москва]. – 2023. – Т. 67, № 1. – С. 39–47. – Библиогр.: 24 назв.(Effectiveness of a course treatment with palmitoylethanolamide and transplantation of mesenchymal stem cells in experimental peripheral neuropathic pain) |
Aim. To study the efftect of repeated intraperitoneal administration of palmitoylethanolamide (PEA, 1 mg/kg) in combination with a single intramuscular injection of adipose-derived mesenchymal stem cells (ADMSCs, 1×106 cells/kg) on nociceptive reactions and morphological changes in tissues of the hind legs of rats with peripheral neuropathic pain (PNP) due to sciatic nerve transection. Methods. The study was conducted on 28 Wistar male rats. The study design included modeling of NP without treatment; NP with a single transplantation of ADMSCs; and NP with a single local transplantation of ADMSCs and a course treatment with PEA. The mechanical withdrawal threshold (MWT) and the thermal withdrawal latency (TWL) were measured weekly for 28 days and on day 60. On day 21 of experiment, the histological structure of soft tissues and neurovascular bundle of the hind paws of NP rats was assessed after transplantation of ADMSCs alone and in combination with the PEA course treatment. Results. A single administration of ADMSCs increased the MWT and TWL in rats with PNP to the baseline values of postoperative day 21, inhibited inflammation of perineural tissues, and improved neovascularization of the vascular bundle in the sciatic axotomy area. A course of PEA intraperitoneal injections in combination with the ADMSCs transplantation increased MWT after the first PEA injection but did not result in recovery of the nociceptive sensitivity to mechanical and thermal stimuli throughout the study, and also abolished the anti-inflammatory effect of ADMSCs. Conclusion. A combination of repeated PEA injections and ADMSCs reduced the antinociceptive effect of stem cells and abolished their anti-inflammatory effect in the area of sciatic nerve resection. |
| Станько, Д. Э. Современный подход к оценке показателей качества жизни женщин с рецидивирующим бактериальным вагинозом в процессе комплексного лечения / Д. Э. Станько (Гродно), Э. П. Станько (Гродно), С. А. Игумнов // Психическое здоровье [Москва]. – 2023. – Т. 18, № 3. – С. 16–27. – Библиогр.: 14 назв.(Modern approach to the assessment of quality of life indicators of women with recurrent bacterial vaginosis in the process of complex treatment) |
Comparison of quality of life indicators before and after treatment is one of the criteria for the effectiveness of treatment of recurrent bacterial vaginosis. The frequency of recurrences and the severity of bacterial vaginosis determine the choice of a specific therapeutic intervention. Objective: to evaluate the quality of life indicators of women with bacterial vaginosis before and after treatment, as well as after 3, 6 and 9 months of dynamic follow-up. Methods. Bacterial vaginosis treatment was carried out in the three studied groups: in group I women (35) the traditional scheme of bacterial vaginosis therapy was used. Women of groups II (30) and III (30) were treated in accordance with the countercidal scheme developed by us, including gynecological baths, septomyrin-gel, oral administration of ornidazole, suppositories with clindamycin and subsidized lactobacilli. After correction of the vaginal biocenosis, the women of group III underwent destruction of the complicated form of cervical ectopia by a combined method, including radiosurgery of the cervix and simultaneous elective cryodestruction of the cervical canal. Results, after the use of the developed by us antiretroviral scheme of treatment of bacterial vaginosis in women, the groups registered an increase in the indicators characterizing the quality of life. Satisfaction with the quality of life after 3, 6 and 9 months after the course of treatment in women of groups II and III was statistically significantly higher than in women of group I. Conclusion. Assessment of the results of treatment of women with bacterial vaginosis using efficacy criteria that include a quality of life score is recommended for practical application as a new method for determining the therapeutic effectiveness of treatment of women with bacterial vaginosis. Violations of social and mental components of the quality of life in women with bacterial vaginosis may serve as indications for inclusion of psychopharmacological correction methods and psychotherapeutic effects in the treatment process. |
| Змитрукевич, А. С. Артериальная гипертензия при COVID-19 / А. С. Змитрукевич, А. Е. Мамедова (Гродно) // Клиническая медицина [Москва]. – 2023. – Т. 101, № 1. – С. 26–31. – Библиогр.: 44 назв.(Arterial hypertension in COVID-19) |
The SARS-CoV-2 virus caused the COVID-19 pandemic. Arterial hypertension in COVID-19 plays an important role in the prognosis of morbidity and mortality. Objective. A brief report on the effect of COVID-19 on arterial hypertension. Discussion. COVID-19 is often accompanied by changes in the cardiovascular system. Arterial hypertension is one of the most common comorbid conditions. A lot of studies have proved the connection of hypertension with COVID-19. The main mechanisms for increasing blood pressure indicators may be: an increase in the concentration of angiotensin II in the blood, the interaction of SARS-CoV-2 with the APF2 receptors of the infected cell membrane, direct and indirect effects on the endothelium, a decrease in the level of vasodilating factors (nitric oxide (NO) and prostacyclin), psychological pressure by the COVID-19 pandemic. Conclusions. Physicians and general practitioners should be aware of hypertension in the management of patients with COVID-19, and the prophylactic medical examination of the population. |
| Генетический спектр семейной и спорадической дилатационной кардиомиопатии: аритмические фенотипы, ассоциированные с мутациями в гене ламина A/C (LMNA) / Т. Г. Вайханская (Минск), Л. Н. Сивицкая (Минск), Т. В. Курушко (Минск), О. Д. Левданский (Минск), Н. Г. Даниленко (Минск) // Евразийский кардиологический журнал [Москва]. – 2023. – № 2. – С. 26–37. – Библиогр.: 17 назв.(Genetic spectrum of familial and sporadic dilated cardiomyopathy: arrhythmic phenotypes associated with mutations in the lamin A/C (LMNA) gene) |
Purpose. To study the diagnostic value of cascade family screening and the spectrum of genetic variants in patients with familial and sporadic DCM, assess clinical outcomes and comparative analysis of 5-year event-free survival. Materials and methods. The study included 156 unrelated patients with verified DCM. All patients (aged 46 [34; 57] years; 125 (80%) male; LVEF 31 [24; 38]%; LV EDD 68 [61; 74] mm; follow-up period – 77 [59; 108] months) a complex of clinical and instrumental studies (ECG, ECHO, HM, MRI), cascade family screening with genetic testing (NGS+Sanger) and segregation analysis were performed. Results. Criteria for familial DCM were identified in 73 (46.8%) probands. The genetic cause of DCM was identified in 47 (64,4%) familial cases, while for sporadic form DCM pathogenic variants were detected in 19 (22,9%) patients. The dominant mutations were truncating variants in the titin gene (10,9%) and variants in the lamin A/C (LMNA) gene – 8,33%. As a result of the evaluation of cumulative event-free survival (Kaplan-Meier curves), LMNA carriers showed the poor 5-year prognosis for ventricular tachyarrhythmic events (x ² =39.9; p=0,0001) and composite adverse outcomes (x ² =12.1; p=0.001). Probands who had a familial DCM (log rang x ² =38.5; p=0,0001) showed the worst prognosis and low cumulative survival when compared with patients of the sporadic DCM. Conclusion. Cascade clinical family screening and genetic testing in the DCM cohort increased the level of diagnosis of familial DCM from 4.5% to 46.8%. Associations of LMNA mutations with life-threatening tachyarrhythmias are defined as prognostically significant, that confirms the important role of genetic stratification of arrhythmic risk. |
| Плоткин, Ф. Б. Доступность психологической и психотерапевтической помощи в Республике Беларусь: иллюзии и реальность / Ф. Б. Плоткин (Минск), Т. В. Короткевич (Минск) // Независимый психиатрический журнал [Москва]. – 2022. – № 4. – С. 38–43. – Библиогр.: 20 назв.(Availability of psychological and psychotherapeutic assistance in the Republic of Belarus: illusions and reality) |
Some circumstances causing the disorder of personal functioning and interpersonal relations in the Republic of Belarus in recent times are indicated. Attention is drawn to the increasing demand of the population for psychological and psychotherapeutic services. The peculiarities of the formation of the staff of psychotherapeutic services in the Republic of Belarus are considered. International standards in training psychotherapists and the statements of authoritative specialists concerning the current state of affairs in this field in the post-Soviet space are given. The situation with the growing number of people in the country who receive a simplified psychologist diploma and provide unlicensed psychological assistance to the population without any control by the professional community is analyzed. Cautious doubts are expressed about the quality of such assistance. The circumstances of the choice of the medical profession are considered. Some personal characteristics of people who choose medicine as their profession, and especially the branches related to mental health care, are characterized. Reference is made to the potential selection of candidates for the medical profession. |
