In this section you can read abstracts of publications from journals of the Republic of Belarus and the Russian Federation on COVID-19. To order the full text use Electronic Medical Library https://mednet.by/ or Electronic Document Delivery service https://mednet.by/pravila-edd.html.
| Тиллоева, З. Х. Результаты лечения больных туберкулезом с множественной лекарственной устойчивостью среди ключевых групп населения в период пандемии COVID-19 в г. Душанбе, Таджикистан / З. Х. Тиллоева, А. С. Мирзоев // Туберкулез и болезни легких. – 2024. – Т. 102, № 3. – С. 24–33.
(Results of Treatment of Patients with Multiple Drug Resistant Tuberculosis among Key Populations during the COVID-19 Pandemic in Dushanbe, Tajikistan.) |
The objective: to identify changes in the effectiveness of treatment of multiple drug-resistant tuberculosis among key populations in Dushanbe, including the period of the COVID-19 pandemic. Subjects and Methods. A retrospective study of medical records of 431 MDR TB patients registered for treatment in Dushanbe was conducted (2017-2019 – Group 1 and 2020-2021 – Group 2 (the COVID-19 pandemic period)). Results. The duration of treatment was 15.4±6.9 months in Group 1, and 10.8±4.3 months in Group 2, which was due to the introduction of short-course regimens in that group. At the same time, in Group 2 there was an increase in the effectiveness of MDR TB treatment to 85% versus 80% in Group 1, due to the use of new drugs and regimens containing them. In Group 1, a statistically significant association was found between MDR TB treatment failure and the following parameters: male gender (RR=2.3 (1.36-4.04), p=0.002), positive HIV status (RR=2.35 (1.37-4.05), p=0.011), hepatitis C infection (RR=3.0 (1.87-4.8), p <0.001), alcohol (RR=3.2 (1.96- ),p<0.001) and substances abuse (RR=3.99 (2.5-6.2), p<0.001), previous imprisonment (RR=2.6 (1.48-4.6), p<0.001), unemployment (RR=3.5 (1.8-6.7), p <0.001), and homelessness (RR=5.0 (3.9-6.5), p=0.0011). In Group 2, failure of MDR TB treatment was statistically significantly associated with hepatitis C (RR=3.3 (1.5-7.2), p=0.02), alcohol and drug abuse (RR= 4.4 ( 1.95-10.1). p =0.026), as well as (unlike Group 1) labor migration (RR=3.0 (1.45-6.2), p=0.0068), in-patient treatment (RR=3.8 (1.36-10.64), p=0.0056). At the same time, there was no association with HIV status. |
| Варламов, Р. К. Влияние ограничительных мероприятий по COVID-19 на выявляемость туберкулеза у детей и подростков / Р. К. Варламов, Е. С. Прокопьев, Е. Ф. Лугинова // Туберкулез и болезни легких. – 2024. – Т. 102, № 3. – С. 71–75.
(Impact of the COVID-19 Restrictive Measures on Tuberculosis Detection among Children and Adolescents) |
The objective: to assess impact of the COVID-19 restrictive measures on tuberculosis detection among children and adolescents. Subjects and Methods. For the analysis, materials from statistical collections and state statistics forms (Form No. 33) were used. Changes of the main epidemiological tuberculosis rates were assessed for two observation periods: before the pandemic (2017-2019) and during the pandemic (2020-2022). Statistical analysis methods were used. Results. The COVID-19 pandemic and related restrictive measures generally provided no significant impact on the coverage with preventive screening for tuberculosis of population in the Republic of Sakha (Yakutia). At the same time, during the pandemic, a slight reduction of the main epidemiological tuberculosis rates was noted both among adults and children. Despite this decrease, a deterioration in the structure of new tuberculosis patients was revealed, which indicated that the disease was not detected in a timely manner. |
| Дифференциальная диагностика мультисистемного воспалительного синдрома, гриппа, острой коронавирусной инфекции COVID-19 с наличием фебрильных судорог и генерализованной менингококковой инфекции у детей / Д. В. Савицкий [и др.] // Клиническая инфектология и паразитология. – 2024. – Т. 13, № 2. – С. 193–206.
(Differential Diagnosis of Multisystem Inflammatory Syndrome, Influenza, Acute Coronavirus Infection COVID-19 with the Presence of Febrile Seizures and Generalized Meningococcal Infection in Children) |
Multisystemic infl ammatory syndrome in children (MIS-C) is a rare severe complication of COVID-19. In children with signs and symptoms consistent with MIS-C the differential diagnosis is broad and includes other infectious and infl ammatory conditions such as infl uenza, severe acute COVID-19, bacterial sepsis to be considered in children with fever, shock and elevated infl ammation markers and have much in common with MIS-C. The purpose. To identify the similarities and diff erences of clinical-laboratory data in children with multisystem infl ammatory syndrome, infl uenza, acute coronavirus infection (COVID-19) with the presence of febrile seizures and meningococcemia. Materials and methods. Analysis of disease histories of 81 children with diagnosis “multisystem infl ammatory syndrome” (MIS-C) associated with COVID-19; 32 – with the diagnosis of infl uenza; 19 – coronavirus infection (COVID-19) with the presence of febrile seizures and 16 – meningococcal infection, meningococcemia. MIS-C was diagnosed according to CDC/WHO, 2020, 2023. Diagnosis of infl uenza, coronavirus infection, meningococcal infection – based on clinical data and laboratory studies. All calculations were carried out in statistical package R, version 4.1. The results of the analysis were considered statistically signifi cant at p<0.05. The scale of probability of MIS-C in children by the method of multifactor variance analysis has been developed. The results. Clinical-laboratory, instrumental indicators of vital functions in children 4 groups have been studied. On the basis of the obtained data, a preliminary one-factor analysis of predictors of development (availability) MIS-C was carried out. It was found that unlike the control group (n=59) patients with MIS-C had such signs as: older age – 96 [65; 145] months, higher CRP level – 148 [80; 193] mg/l, rash – 67 (82.7%), scleritis – 58 (71.6– 54%), cheilitis – 43%), oedema – 35 (43.2%) gastrointestinal tract lesions are 51 (63.0%), neutrophils and Erythrocyte Sedimentation Rate 53 (65.4%) and 61 (75.3%), respectively (p-value<0.001), and leukocytosis –32 (39.5) (p-value<0.001). According to the results of one-factor analysis, a multi-factor analysis was conducted. Through logistic regression, predictors were identifi ed that remained statistically signifi cant while infl uencing the MIS-C odds. Conclusion. Taking into account the diversity and ambiguity of characterization of described characteristics for diff erentiation of diagnoses, on the basis of multi-factor analysis we have determined four basic traits of MIS-C in children – it is cheilitis, edema, high CRP (>55 mg/l), gastrointestinal tract lesions. The presence of two of the four signs indicates a high probability of MIS-C in the patient, which is extremely important in the initial stage of medical care until the full results of the patient’s examination. |
| Маркеры наследственной отягощенности по склонности к гемостатическим нарушениям при COVID-19-инфекции, ассоциированной с хроническими вирусными гепатитами / М. Д. Ахмедова [и др.] // Клиническая инфектология и паразитология. – 2024. – Т. 13, № 2. – С. 207–215
(Markers of Hereditary Aggravation for Susceptibility to Haemostatic Disorders in COVID-19 Infection Associated with Chronic Viral Hepatitis) |
The purpose. To investigate genetic markers of hereditary aggravation for susceptibility to hemostatic disorders in COVID-19 infection associated with chronic viral hepatitis. Materials and methods. 96 (100%) patients were included in the study, including 48 (50%) patients with a moderate form of COVID-19 infection occurring in the background of CVC and 48 (50%) patients with a severe form of the disease with the highest indicators of D-dimer and IL-6 levels, including 5 with lethal outcome. The number of patients with HCV and HDV was equal. Clinical features and results of laboratory methods of investigation of the examined patients were recorded in individual patient registration cards – electronic chips on Microsoft Excel Sheets. The average age of patients with moderate form of COVID-19 infection with CVH background was 49,63±1,75 years, and patients with severe form of the disease was 52,94±1,95 years, of them with fatal outcome 60,4±6,19 years. The determination of polymorphism rs699947 of VEGFA gene -2578 C/A and rs1570360 of VEGFA gene -1154 G/A by PCR was performed. Results and discussion. It was revealed that the duration of chronic viral hepatitis (more than 10 years) in patients with COVID-19 infection directly aff ects the severity of the disease. It was found that homozygous mutation (AA) of VEGFA -2578 C/A gene of rs699947 locus was signifi cantly more frequently (1.43 times higher) detected in severe form (20.83%) than in moderately severe form of COVID-19 associated chronic viral hepatitis (14.6%). The same pattern was noted in the VEGFA gene -1154 G/A locus rs1570360, where the homozygous mutation (GG) in the severe form was 33.33% and in the moderate form 8.33%, i. e. it was 2-fold higher. Both in patients with moderate and in patients with severe form of COVID-19 infection occurring against the background of Chronic viral hepatitis, polymorphism AA in contrast to AC, CC of locus rs699947 of VEGFA gene -2578 C/A and polymorphism GG in contrast to GA, AA of locus rs1570360 of VEGFA gene -1154 G/A predispose signifi cantly (p<0,05) to high content of IL-6 levels, which became a reliable cause of infl ammatory process development (CRP 59,54±13,74 and 62,28±14,02 mg/ml respectively), systemic tissue damage (TNF level 17,57±0,43 and 18,03±0,39 pg/ml), predisposing to increase of D-dimer level and thrombophilia in this category of patients. Conclusions. The data obtained by us indicate the association of polymorphism AA of locus rs699947 of VEGFA gene -2578 C/A and GG of locus rs1570360 of VEGFA gene -1154 G/A with the formation of severe form of COVID-19 infection occurring in the background of CVD, thrombophilia, infl ammation and systemic tissue damage. |
| Профессиональное выгорание и качество жизни медицинских сестер в период пандемии COVID-19 / С. А. Бабанов [и др.] // Медицинская сестра. – 2024. – Т. 26, № 4. – С. 44–52.
(Professional burnout and quality of life of nurses during the COVID-19 pandemic) |
Introduction. In the context o f the COVID-19 pandemic, average medical workers turned out to be the most vulnerable category among medical workers in terms o f professional stress, professional burnout, and a decrease in quality o f life. Goal. To establish the features of professional burnout and the quality of life of MS in specialized COVID hospitals, multidisciplinary hospitals (MP hospitals), as well as polyclinics (PCs) during the pandemic o f the new coronavirus infection COVID-19. Material and methods. The study was performed at the Department of Occupational Diseases and Clinical Pharmacology named after the Honored Scientist o f the Russian Federation, Professor V.V. Kosarev o f the Federal State Budgetary Educational Institution o f the Ministry o f Health o f the Russian Federation and the Regional Center o f Occupational Pathology of the Samara City Hospital No. 5. The following MS groups were examined: the first group consisted o f nurses working in a COVID hospital (n=29); the second group consisted o f nurses working in a multidisciplinary hospital (n=31); the third group consisted o f nurses working in polyclinics (n=29); The fourth, control group (GC), included employees o f engineering, technical and economic specialties that are not related in their field o f activity to work in medical organizations (n=190). The assessment of professional burnout syndrome was carried out using the Maslach Burnout professional burnout assessment questionnaire, the V.V. Boyko questionnaire, the quality o f life was determined using the SF-36 questionnaire. Results. It has been established that the work o f MS during the COVID-19 pandemic is associated with the impact on medical workers o f a number o f specific risk factors related to the provision o f medical care to infected patients, as well as with significant changes in work regarding aspects related to organization, safety, which contribute to an increase in the level of occupational stress, professional burnout, and a decrease in the quality of life. Conclusion. The work of MS in a COVID hospital, when compared with MS in hospitals, nurses working in polyclinics, is associated with an increase in the level of professional stress, the level of professional burnout. It is necessaty to continue research on the emotional state of MS in order to timely cany out preventive treatment to preserve the health o f this category o f medical workers. Limitations of the study. The study has regional (Samara region) and professional (in terms o f detailing the working conditions in the studied comparison groups) limitations. Compliance with ethical standards. The study was carried out within the framework o f the complex topic o f the Department o f Occupational Diseases and Clinical Pharmacology named after Honored Scientist of the Russian Federation Professor V.V. Kosarev o f the Federal State Budgetaiy Educational Institution o f the Russian Ministiy o f Health o f the Ministiy of Health of the Russian Federation «А systematic approach to early diagnosis, prevention and prediction o f the impact of low-intensity industrial factors on the health o f workers» (state registration number AAAA18- 118122190069-6, date registration on December 21, 2018). The study was approved by the local Ethics Committee of the Federal State Budgetaiy Educational Institution of the Russian Ministiy of Health on 11/23/2021. |
| Поражение суставов у пациентов с COVID-19 в работе медицинской сестры / В. В. Скворцов [и др.] // Медицинская сестра. – 2024. – Т. 26, № 4. – С. 53–56.
(Joint damage in patients with COVID-19 in family medicine) |
Rheumatoid pathology of the articular apparatus is a significant social problem due to the high incidence of disability. Cases of the development of arthropathy after SARS-CoV-2 infection have been described. The basis of the pathogenesis of this condition may be the excessive synthesis of pro-inflammatory cytokines (cytokine storm), which is characteristic of the acute course of COVID-19. In patients with a severe form of the coronavirus infection, a high concentration of a number of cytokines IFN-γ, IL-1, IL-6, IL-12, and TGFβ was observed. Due to the activation of osteoclasts, resorptive processes in bone tissue were significantly enhanced. Autoimmunization due to cross-reactivity of the virus can also lead to joint damage. Reactive arthritis tends to be acute and occurs in the form of monoarthritis or oligoarthritis. The pathological process develops mainly in the joints of the wrist, ankles, and small joints of the distal parts of the limbs. |
| Налетов, А. В. Некоторые клинико-патогенетические аспекты синдрома раздраженного кишечника у пациентов, перенесших COVID-19 / А. В. Налетов, Т. И. Шапченко, Н. П. Гуз // Экспериментальная и клиническая гастроэнтерология. – 2023. – № 7. – С. 60–65.
(Some clinical and pathogenetic aspects of irritable bowel syndrome in COVID-19 patients) |
One of the manifestations of C0VID-19 is gastrointestinal complaints, the frequency of which varies from 3% to 80% of patients. The article presents modern data on the pathogenesis of irritable bowel syndrome and peculiarities of the clinical picture of this disorder in C0VID-19 patients. The influence of SARS-Cov-2 on the main pathogenetic links of irritable bowel syndrome is indicated. The problem of gastrointestinal tract damage in C0VID-19 is not fully understood and remains as relevant as the occurrence of pathological processes in the respiratory tract. |
| Лебедева, Т. Н. Дебют аутоиммунного гепатита после перенесенной новой коронавирусной инфекции (COVID-19) у ребенка 11 месяцев / Т. Н. Лебедева, А. Ю. Марчукова, К. Г. Бондарь // Экспериментальная и клиническая гастроэнтерология. – 2023. – № 7. – С. 156–161.
(The debut of autoimmune hepatitis after a new coronavirus infection (COVID-19) in an 11-month-old child) |
In many countries fix cases of severe liver damage in children are recorded. A previous or existing coronavirus infection leads to a disruption in the body’s immune response to infections, which can lead to severe inflammation that caused liver damage. This article describes a clinical case of type 2 autoimmune hepatitis, a high degree of biochemical activity, that debuted in an 11-month-old child after a new coronavirus infection (COVID-19). The presented clinical example demonstrates the need for a thorough and comprehensive examination of children with the first clinical manifestations of liver damage and timely prescription of therapy. |
| Взаимодействие SARS-CoV-2 с кишечной микробиотой / О. В. Солдатова [и др.] // Экспериментальная и клиническая гастроэнтерология. – 2023. – № 12. – С. 59–67.
(Interaction of SARS-CoV-2 with gut microbiota) |
The aim of the review is to determine the influence of gut microbiota on the severity of the course and development of complications of a new coronavirus infection C0VID-19, as well as to consider the possibility of effective use of probiotics, prebiotics and metabiotics as adjuvant therapy to improve the body’s resistance to viral infections. Recently, much attention has been paid to the influence of the gut microbiota on the course of many internal diseases of both infectious and non-infectious nature. The pathogenetic influence of changes in intestinal microbiota on the initiation and maintenance of inflammatory and immune response of the organism has been proved. A direct correlation between increased susceptibility of the human gut microbiota to a new coronavirus infection and the occurrence of complications from the respiratory system has been observed in a number of studies. Changes in the intestinal microbiome lead to increased intestinal permeability and, consequently, to a decrease in protective barrier and immune mechanisms of the gastrointestinal mucosa, resulting in easier and faster penetration of SARS-CoV-2 virus into the bloodstream with subsequent systemic dissemination. In the light of the available data, a close relationship between the severity of new coronavirus infection and the composition of the gut microbiota is highly likely. In this article we present the results of some studies on the basis of which we can conclude about the changes in the gut microbiota of C0VID-19 patients and the efficacy of pro-, pre- and metabiotics in their treatment, including lactobacilli strains and antimicrobial peptides (AMPs) to improve prognosis and prevent complications. The information presented may be useful to enhance the therapeutic effect of standard therapies. The research presented in this article confirms that taking pro-, pre- and metabiotics has anti-inflammatory, immunomodulatory potential and contributes to a faster recovery of the patient. It can also be taken for prophylactic purposes to strengthen the body’s resistance and modulate the immune system. |
| Громова, О. А. Хемомикробиомное исследование преобиотических и антибиотических свойств биофлавоноидов и полифенолов, перспективных для лечения COVID-19 и других вирусных инфекций / О. А. Громова, И. Ю. Торшин, А. Г. Чучалин // Экспериментальная и клиническая гастроэнтерология. – 2023. – № 12. – С. 68–76
(Chemomicrobiome study of the preobiotic and antibiotic properties of bioflavonoids and polyphenols promising for the treatment of COVID-19 and other viral infections) |
When investigating promising drug molecules for C0VID-19 therapy, it is important to evaluate their prebiotic and antibiotic characteristics, i.e. their effects on the growth of beneficial and pathogenic microbiota. In the present study, chemomicrobiome analyses of 5 bioflavanoids (hesperidin, leucodelphinidin, rutin, quercetin, baicalin), 2 polyphenols (curcumin, epigallocatechin gallate) and their synergistic substances (glycyrrhizin saponin and piperine alkaloid) were obtained for 38 human commensal bacteria and for 152 strains of pathogenic microorganisms. The molecules studied significantly supported the growth of the beneficial microbiota: for each of the molecules the AUC values were 0.67..0.79 uC (averaged over the sample of 38 commensals) and were characterised by good safety scores. Rutin and glycyrrhizin contributed the most to the support of the beneficial microbiota (AUC 0.78±0.14 u.u.), while baicalin contributed the least (AUC 0.66±0.24 u.u.). Synergistic interaction between the studied substances was established: when 9 substances are co-administered together, the average AUC value may increase up to 0.84±0.06 u.u. Glycyrrhizin (19.2±12.1%) is most actively metabolised by Normobiota, and piperine (6.0±5.9%) is least actively metabolised. The most active metabolisers of the studied substances were bacteria of the genus Bocteroides (more than 30%), the least active were bacteria of the genus Collinsello (<1%). The results of chemomicrobiome analysis of the studied molecules in volunteers with different microbiome profiles confirmed that the studied substances do not promote the growth of pathogenic flora. The investigated substances can inhibit the growth of pathogenic Acinetobacter baumannii, Candida albicans, Candida glabrata, Cryptococcus neoformans, Klebsiella pneumoniae, Pseudomonas aeruginosa, Staphlococcus aureus, Staphylococcus epidermidis, Streptococcus pneumoniae, Streptococcus pyogenes (MIC values of about 10-25 µg/ml). |
| Эффективность синбиотика “Максифлор Максимум” для коррекции гастроинтестинальной дисфункции у пациентов, перенесших COVID-19 / Т. М. Богданова [и др.] // Экспериментальная и клиническая гастроэнтерология. – 2023. – № 12. – С. 103–110.
(The efficacy of the Maxiflor Maximum synbiotic for the correction of gastrointestinal dysfunction in patients after COVID-19) |
The aim of the study: to evaluate the effect of the Maxiflor Maximum dietary supplement on the severity of dyspepsia and colon microbiota in patients who had a new coronavirus infection and were treated with antibacterial drugs. Materials and methods. The study included 60 patients with gastrointestinal symptoms who had a novel coronavirus infection and received antibacterial drugs for at least 7 days to treat complications of COVID-19. Of these, 30 people made up the “Treatment” group and received the biologically active supplement “Maxiflor Maximum” at a dose of 1 capsule per day for 4 weeks. 30 people were observed prospectively in the Control group. Analysis of subjective status was carried out using the Russified Gastrointestinal Symptom Rating Scale (GSRS) questionnaire. All patients underwent fecal analysis for dysbacteriosis. The questionnaire and microbiological test were performed on the first day of the study, and again after 10 and 30 days. Discussion. The severity of gastroenterological symptoms after 4 weeks of “Maxiflor Maximum” therapy was statistically significantly lower than in the control group. There was a significant subjective improvement in well-being – a decrease in the frequency of abdominal pain, the intensity of dyspepsia, the frequency of stools normalized (p<0.05). A positive dynamics of intestinal microbiota indicators was registered in the “Treatment” group. The number of opportunistic representatives of the microflora decreased statistically and the pool of beneficial saprophytes increased (p<0.05). In the “Control” group, there was a lack of statistically significant changes in the state of the intestinal microbiota. Conclusion. The dynamics of clinical and laboratory parameters reflecting the course of COVID-19 indicates the effectiveness of using the Maxiflor Maximum synbiotic as an adjuvant therapy, and makes it possible to recommend it for use in the complex treatment of patients with a new coronavirus infection. |
| Гипераммониемия как проявление постковидного синдрома у пациентов с неалкогольной жировой болезнью печени: post-hoc анализ наблюдательной клинической программы ЛИРА – COVID / Л. Б. Лазебник [и др.] // Экспериментальная и клиническая гастроэнтерология. – 2023. – № 12. – С. 140–147.(Hyperammonemia as a manifestation of post-ovoid syndrome in patients with non-alcoholic fatty liver disease: post-hoc analysis of the observational clinical programme LIRA – COVID) | Post-coronavirus syndrome (PCS) is considered as a consequence of the coronavirus infection. The liver in COVID-19 is one of the most frequently affected organs, with the development of asthenia, cognitive impairment, and increased activity of alanine and asparagine transaminases (ALT and AST) persisting in some patients up to 4-6 months after hospital discharge. The cause of asthenia may be hyperammonemia (HA), which in C0VID-19 is a manifestation of hepatic dysfunction on the background of direct cytotoxic action of SARS-CoV-2 on hepatocytes, which was shown earlier within the protocol of the clinical observation programme ‘Clinical significance of hyperammonemia in patients with post-CoVID (LIRA-CoVID)’. Due to the great urgency of the problem of the combination of PCS, nonalcoholic fatty liver disease (NAFLD) and HA, a post-hoc analysis of the LIRA-COVID clinical observational programme was performed. It was shown that NAFLD has a significant effect on AST levels before L-ornithine-L-aspartate treatment. The presence of NAFLD has a significant effect on ammonia level after 14 days of treatment, as the ammonia level was significantly higher in the group of patients with NAFLD than in the group without NAFLD. On the basis of post – hoc analysis of the results of the LIRA – COVID study it was concluded that it is reasonable to include in the scheme of examination of patients with postcovoid syndrome, including patients with NAFLD, determination of blood ammonia level, in case of its increase it is justified to prescribe L-ornithine – L-aspartate preparation to such patients for a course of 4 weeks at a standard dose of 9 g per day. |
| Селицкая, О. П. Прогноз при COVID-19 / О. П. Селицкая // Медицинский журнал.
(Prognosis with COVID-19) |
It is important to identify and clarify the role of clinical and laboratory parameters in assessing the unfavourable prognosis of COVID-19, allowing to identify patients at risk at an early stage of the pathological process. The aim of this work was to identify clinical and laboratory predictors affecting the worsening prognosis and mortality in COVID-19. Materials and Methods. The study was carried out on the basis of the 5th City Clinical Hospital in Minsk. 240 patients with severe form of COVID-19 participated in the study. Results. According to the results of the study in the group of deceased patients the persons of older age group prevailed, the average index of comorbidity of pathologies in the group of survivors was 2 pathologies (max 7, min 0), in the group of deceased – 2 pathologies (max 10, min 0, Me 3), which had statistically reliable difference at the level of p = 0,00006. Among complications, the most frequently recorded were DN of 1-3 degree (in 84.87 % of surviving patients and 71.9 % in deceased patients), pulmonary edema (in 2.52 and 12.4 % of patients, respectively), SION (in 5.88 and 19.83 % of patients, respectively). A decrease in Sp02 less than 93 % significantly reduced the chances of recovery (OR 0.422; 95 % CI 0.138-0.637). An elevation of CRP level > 5 mg/L had a significant association with adverse COVID-19 outcome (OR 2.721; 95% CI 1.342-6.657). Conclusion: Factors affecting prognosis in COVID-19 were older age, desaturation less than 93% (y2 = 245.211; p < 0.0001), high percentage of comorbidity p = 0.00006 (p < 0.05), leucocytosis (u2 = 18.36; p < 0.001), increased levels of C-reactive protein (u2 = 132.455; p < 0.001), procalcitonin, IL-6, D-dimers (у2 = 161,122; р < 0,001). |
| Изменения микробного пейзажа глотки в постковидный период / Е. И. Саливончик [и др.] // Медицинский журнал.
(Changes in the microbial landscape of the pharynx in the post-COVID period) |
Introduction. The microbial landscape of a pharynx at the period of COVID-19 pandemic, compared to the pre-Covid period, have a great practical and scientific importance. Purpose. We determine the microbial landscape in patients with pharyngitis during the pandemic of the new coronavirus infection COVID-19 and the dynamics of antibiotic resistance of the most common types of microorganisms in comparison with the “pre-Covid” period. Materials and methods. We estimated 403 samples of throat culture from patients with pharyngitis. The main group consists of 308 samples from patients during the COVID-19 pandemic (2020–2022 years). The comparison group consists of 95 samples taken in 2019 year. Results. We reveal the following features of throat culture: Gram-positive flora, mainly S. aureus, decreases by 2 times, and Candida spp. increases by 2 times in patients with pharyngitis during the COVID-19 pandemic, compared with the pre-Covid period, p < 0.05. Kl. pneumonia slightly increases up to 18 % in 2020. Enterococcus spp., on the contrary, had a slow but steady trend towards an increase from 5 % in 2019 to 12 % in 2022 (p > 0.05), which may indicate the development of pharyngeal dysbiosis that occurs during treatment of COVID-19 infection. Throat culture bacteria increase resistance to semisynthetic penicillins: S. aureus rom 4 % to 12–30 % (p < 0.05), Klebsiella pneumoniae from 33 % in 2019 to 54 % in 2021 (p < 0.05), with a subsequent decrease to 28 % in 2022. Klebsiella pneumoniae also increases resistance to fluoroquinolones from 25 % in 2019 to 40 % in 2021 (p < 0.05) |
| Тушова, К. А. Патогенетические и клинико-неврологические особенности постковидного синдрома / К. А. Тушова, Н. В. Ноздрюхина, Е. Н. Кабаева // Вестник неврологии, психиатрии и нейрохирургии
(Pathogenetic and clinical and neurological features of postcovid syndrome) |
Despite the developed methods of treatment and prevention of COVID-19, new strains of SARS-CoV-2 virus continue to appear. Against the background of COVID-19 coronavirus infection, the development of complications from various organs and systems is noted. In patients with three or more chronic diseases, the infection can proceed with varying degrees of severity, often leading to the formation of acute vascular accidents. Such patients have an unfavourable rehabilitation prognosis due to the severe course of the disease. The complex of symptoms that manifests itself with various psychoemotional and functional disorders after a coronavirus infection is called postcovid syndrome. This syndrome develops 3-4 months after COVID-19 infection. The scientific community has put forward a number of hypotheses describing the pathogenetic features of postcovid syndrome. It is a proven fact that the development of this syndrome is associated with the main pathogenetic mechanisms and course of COVID-19 – disturbance in the haemostasis system and hyperproduction of inflammatory cytokines with the development of a ‘cytokine storm’. Post-CoVID-19 syndrome is characterised by a wide spectrum of symptomatology, the manifestation of which does not depend on the severity of previously experienced COVID-19. However, among patients with chronic pathology of the cardiovascular system there is a more severe manifestation of postcovid syndrome, with the risk of acute vascular accidents. The article presents an analysis of modern literature data on the clinical and neurological features of the development and course of postcovid syndrome. |
| Новиков, В. В. Cовременные особенности психического состояния лиц, перенесших COVID-19 / В. В. Новиков, Д. Ф. Хритинин // Вестник неврологии, психиатрии и нейрохирургии. – 2024. – Т. 17, № 6. – С. 778–783
(Current peculiarities of the mental state of COVID-19 survivors) |
The emergence of mental disorders, sometimes in a latent form, is observed in COVID-19 survivors, which prompted us to investigate the most characteristic and stable manifestations of the mental component of the post-COVID syndrome in survivors without a history of mental disorders. It was found that the final formation of stable symptomatology occurs within a year and includes mainly asthenic, cognitive and anxiety disorders, which are in mutual influence and are present against a background of constant low mood, not reaching the degree of depression, which significantly reduces the quality of life. |