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In this section you can check out Belarusian author’s publications in foreign periodicals which are accessible in RSML. To order a full text, use Electronic medical library or the Electronic document delivery service.
| Спирин, Н. Н. Место олигопептида H-Met-Glu-His-Phe-Pro-Gly-Pro-OH в терапии и реабилитации пациентов с ишемическим инсультом / Н. Н. Спирин, В. Н. Федоров, В. П. Вдовиченко (Гродно) // Журнал неврологии и психиатрии имени С. С. Корсакова [Москва]. – 2024. – Т. 124, № 8, вып. 2. – С. 56–63. Place of oligopeptide H-Met-Glu-His-Phe-Pro-Gly-Pro-OH in the therapy and rehabilitation of patients with ischemic stroke |
Cerebrovascular diseases (CVDs) are one of the leading causes of death and disability In Russia: they rank second in the structure of mortality from diseases of the circulatory system and in the overall mortality of the population. Successful treatment of CVD involves an integrated approach to the problem, taking into account the compensation of cardiovascular disorders, the elimination of neurological and psychopathological syndromes, the improvement of cerebral circulation and the use of neuroprotective agents that increase the resistance of brain tissue to hypoxia and ischemia. Insufficient clinical efficacy of neuroprotectors is due to a number of objective reasons, of which only two are universal. The first of these reasons is the timing of the start of therapy in the clinic, as a rule, is outside the «therapeutic window»; the second reason is the fact that disturbance of the patency of the cerebral vessels in the affected area makes it difficult or impossible to deliver the drug to the penumbra area. The way out of this situation is the intranasal route of drug administration, which is characteristic for the analogs of regulatory peptides such as for H-Met-Glu-His-Phe-Pro-Gly-Pro-OH (MGHPPGP). The review of clinical studies indicates that MGHPPGP is clinically effective in the treatment of ischemic stroke both in the acute period of stroke and in the recovery period. The clinical efficacy of MGHPPGP was shown both in atherothrombotic and cardioembolic subtypes of stroke, against the background of blood flow disturbances in both the carotid and vertebrobasilar systems. |
| Влияние особенностей воспитания на формирование суицидального поведения / С. В. Давидовский (Минск), С. А. Игумнов (Минск), М. М. Скугаревская (Минск), Ж. А. Ибрагимова (Минск), Я. С. Давидовская (Минск), А. В. Казачок (Минск) // Психическое здоровье [Москва]. – 2024. – Т. 19, № 7. – С. 25–34. Influence of upbringing characteristics on the formation of suicidal behaviour |
Studies of the peculiarities of suicidal behaviour conducted during 2016-2023 in the Republic of Belarus and the Russian Federation revealed that one of the suicide risk factors is the presence of single-parent families. It was found that among the persons who committed suicidal attempts, persons raised in incomplete families prevailed. Methods. In the course of the research we studied social and individual-psychological factors influencing the formation of ‘pro-suicidal’ psychological attitudes. The hypothesis that there is a statistical relationship between the three groups under study was tested using the nonparametric Kruskal-Wallis test. If the hypothesis of the presence of a relationship between the three groups was confirmed, pairwise comparison of distributions was performed using the Mann-Whitney criterion with Bonferroni correction for the level of significance. The hypothesis of a statistical relationship when analysing nominal and ordinal variables was tested using the x2 criterion at a standard significance level of p < 0.05. Results. It has been established that for persons from incomplete families the presence of the character trait ‘stuckness’ is characteristic for the development of certain psychopathological disorders, in contrast to complete families. Persons from complete families are characterised by the presence of a higher proportion of phlegmatics and a lower proportion of melancholics; a lower level of neuroticism and excitability; a high level of demonstrativeness and hyperintimacy and a lower level of dysthymicism and anxiety. At the same time, in the group with RA persons with melancholic type of temperament prevailed (the differences are not reliable compared to the LPV group). Conclusion. For most of the identified psychological indicators (neuroticism, excitability, demonstrativeness, hyper-intimacy, dysthymicism, anxiety) significant differences are manifested only for the conditions of upbringing in a complete family. In the incomplete family category, the study groups differ among themselves in the character trait ‘stuckness’. |
| Выявление добавочного подглазничного отверстия с помощью конусно-лучевой компьютерной томографии / С. Л. Кабак (Минск), Ю. М. Мельниченко (Минск), М. П. Юферева (Минск), А. В. Пильчук (Минск) // Вестник рентгенологии и радиологии [Москва]. – 2024. – Т. 105, № 3. – С. 143–148. Evaluation of Accessory Infraorbital Foramen with Cone Beam Computed Tomography |
Objective: to assess the incidence, number and position of accessory infraorbital foramina (AIOF) according to cone beam computed tomography (CBCT). Material and methods. CBCT data from 156 patients who received dental care at a private medical center in Minsk (The Republic of Belarus) in 2018–2023 were analyzed. Results. In 29 (18.6%) patients, 38 AIOF were found. Unilateral doubling of the infraorbital foramen was more common than bilateral (21 patients compared to 8). In 1 case, the presence of two AIOF simultaneously on one side was noted. They were located medial and superior relative to the main infraorbital foramen at a distance 3.73–14.5 mm from it. In 2 of 13 patients with simultaneously visualized upper and lower jaws, an accessory mental foramen was found on the AIOF side. AIOF were more often identified on the left side (p<0.05); no gender differences in their occurrence were detected. Conclusion. The obtained results demonstrate a high frequency of infraorbital foramen doubling. To increase the effectiveness of surgical manipulations in the middle third of the face and prevent iatrogenic neurological complications, it is recommended to conduct a preoperative CBCT to clarify the localization of the main and accessory infraorbital foramina. |
| Показатели силы дыхательных мышц и оксигенации для прогнозирования длительности госпитализации пациентов с COVID-19 / Е. С. Панько (Брест), С. В. Жаворонок (Минск), А. М. Соловчук (Брест), С. В. Панько (Брест) // Журнал инфектологии [Санкт-Петербург]. – 2024. – Т. 16, № 3. – С. 71–79. Respiratory muscle strength and oxygenation as predictors of length of hospital stay in patients with COVID-19 |
The aim was to analyze the prognostic value of ventilation/ gas exchange dissociation markers to predict the treatment length in patients with the acute phase of COVID-19. Materials and methods: The analysis was performed using a database of 384 randomly selected patients from December 2021 to May 2022 with a confirmed diagnosis of the acute phase of COVID-19, aged 61±16 years. Spirometry of maximal inspiratory pressure (MIP) and maximal expiratory pressure (MEP) was performed on 2,2±0,2 day of hospitalization with a portable MicroRPM device (CareFusion, UK) and measurement of surrogate oxygenation index (SpO2/FiO2), ROX index (SpO2/ FiO2)/respiratory rate) was carried out in all patients. Log-regression models were used (STATISTICA 10) to determine cutoff values for these functional variables and their ability to predict the patients length of hospital stay from the date of examination (≤ 7 vs > 7 days). Results: The lowest sensitivity (SE) and specificity (SP) were shown in models using only the respiratory muscle strength markers MIP (SE=54%, SP=70%) and MEP (SE=73%, SP=47%), that were the same in the combination of MIP and MEP (SE=65%, SP=58%). The areas under ROC were equal to 0.6 in all three models. The models based on hypoxia markers had a higher classification power (AUC 0,7) compared to the previous three, and the sensitivity value was higher in the model using the ROX index (SE = 58% and SP = 78%), but the specificity was better in the surrogate oxygenation index model (SE = 48% and SP = 88%). A complex model based on a combination of the two integral hypoxia indices, as well as a diaphragm strength marker (SpO2/FiO2+MIP*ROX+MIP) had the best sensitivity (67%) and specificity (84%), and the area under ROC reached 0.8. Conclusion: Indicators of respiratory muscle strength and oxygenation are suitable markers for combined models and algorithms for predicting hospital length of stay in COVID-19 patients. и стратификации госпитализированных пациентов в острую фазу COVID-19. |
| Стеняева, Н. Н. Опыт применения комбинированного мелатонин-содержащего средства в коррекции нарушений сна у женщин / Н. Н. Стеняева, Д. Ф. Хритинин, Е. Ю. Стеняев (Минск) // Акушерство и гинекология [Москва]. – 2024. – № 6. – С. 154–160. Experience of using a combined melatonin-containing drug in the correction of sleep disorders in women |
A review of existing research suggests that women are more likely to experience sleep disorders than men. Chronic sleep deprivation results in the activation of the hypothalamic-pituitary system and sympathetic nervous system, which increases the risk of menstrual disorders, ovarian dysfunction, spontaneous abortion, decreased ovarian reserve in women over 35 years of age, and low effectiveness of in vitro fertilization in women with infertility. Sleep disorders such as hypersomnia and insomnia associated with premenstrual syndrome and premenstrual dysphoric disorder have been described. Sleep disorders in women with polycystic ovary syndrome are almost twice as common as in healthy women of the same age. Insomnia is a common complaint in menopausal transition period and in postmenopause in more than half of women. The results of numerous studies emphasize the importance of diagnostics and treatment of sleep disorders for effective correction of the underlying disease that leads to reproductive impairment and reduced quality of life in women. The first-line drug choice in the treatment of insomnia are herbal sedatives and melatonin. Melatonin is a pleiotropic hormone, produced by the epiphysis, that regulates the circadian and seasonal rhythms of physiological functions of the body. It affects not only sleep-wake cycles, but also neuronal development, metabolic processes, protection and regulation of the immune, endocrine and reproductive systems. SonNorm Duo is a combined drug containing melatonin, peppermint leaf oil and motherwort herb extract, which has adaptogenic and sedative effect, helps to reduce the nervous system excitability, reduce anxiety and excitement, improve sleep quality; it also normalizes circadian rhythms, including the sleep-wakefulness cycle and adaptation of weather-sensitive people to weather changes. Due to the gradual release of its components, SonNorm Duo has a higher clinical efficacy relative to mono-melatonin-containing drugs, as well as a high safety profile, and can be used with hormone therapy. Conclusion: The use of the combined drug SonNorm Duo in clinical practice confirms its efficacy and safety in women of reproductive and menopausal age. |
| Комбинированное определение биомаркеров в оценке эффективности лечения аденокарциномы легкого / А. Д. Таганович (Минск), Н. Н. Ковганко (Минск), А. В. Колб (Минск), О. В. Готько (Минская обл.), В. И. Прохорова (Минская обл.) // Клиническая лабораторная диагностика [Москва]. – 2024. – Т. 69, № 5. – С. 184–194. Combined biomarker detection in the assessment of treatment efficacy in lung adenocarcinoma |
There is a need to search for predictors that can serve as an important addition to ongoing monitoring in order to diagnose or predict tumor recurrence in each individual patient as early as possible after surgical treatment. The aim is to study the possibility of using a single laboratory criterion to determine the probability of tumor recurrence in patients with stages I-IIIB AK of the lung. Material and methods. We examined 117 patients (79 men and 38 women) who were first diagnosed with AK of the lung stage I-IIIB (I stage – 28, II stage – 36, I11A, B stage – 53). We measured the concentration of CYFRA 21-1 cytokeratin fragment 19, the density of the CXCR1 receptor on granulocytes and the proportion of lymphocytes equipped with CXCR1, CXCR2 receptors in the total population of these blood cells and the eosinophils/monocytes ratio before treatment and 3 weeks, 3 and 6 months after treatment. Results. A pooled regression equation including the absolute values of 5 individual biomarkers was proposed. The probability of recurrence by measuring the difference of regression equation results after 3 weeks and 3 months, after 3 and 6 months, after 3 weeks and 6 months, after 3 weeks and 6 months after treatment had a diagnostic efficiency of 77.8%, 88.9%, 94.0%, respectively (sensitivity 77.1Uo, 88.6%, 97.1%, specificity 78.0%, 89.0%, 92.7%) with thresholds of 0.063, 0.127, and 0.190, respectively. Conclusion. A nomogram for estimation of the probability of tumor recurrence after treatment was constructed on the basis of the created combined equation. |
| Исследование респираторной функции легких у курящих лиц и больных хронической обструктивной болезнью легких / А. И. Михайловичева, В. В. Смирнов, П. В. Стручков, Н. С. Носенко, А. Г. Сотникова, Е. О. Дьячкова, Т. И. Дивакова, Ю. А. Баженова-Бессонова, И. А. Маничев (Минск) // Клиническая медицина [Москва]. – 2024. – Т. 102, № 3. – С. 241–246. Study of respiratory function of the lungs in smokers and patients with chronic obstructive pulmonary disease |
The article discusses the use of methods for assessing lung respiratory function in patients with chronic obstructive pulmonary disease (COPD) and smokers. The aim of the study is a comparative evaluation of the informative value of capnometry, spirometry, multiple breath nitrogen washout method, and diffusion test in patients with COPD, as well as an early detection of respiratory function impairment in smokers. Results. Three groups of patients were examined: 1st — 30 patients with moderately severe COPD, average age 50.6 ± 4.3 years, 2nd — 30 smokers, average age 45.6 ± 2.4 years, 3rd (control group) — 30 practically healthy non-smokers, average age 45.6 ± 2.4 years. Capnometry showed a statistically significant increase in the slope of the alveolar phase in patients with COPD compared to the control group and smokers at rest, both before and after bronchodilator use. Significant differences between smokers and control groups were detected during forced exhalation. According to spirometry data, the FEV1/FVC ratio in patients with COPD was statistically significantly lower compared to the control group and smokers, both before and after bronchodilator use. Diffusion capacity was significantly lower in patients with COPD and smokers compared to the control group. The lung clearance index was significantly higher in the COPD group compared to the other two groups. Conclusions. All the mentioned methods were informative in patients with COPD, but capnometry and lung diffusion capacity assessment were sensitive methods in smokers, revealing uneven distribution of ventilation-perfusion ratios in the lungs and impaired gas exchange function. |
| Первичная надпочечниковая недостаточность / Т. И. Каленчиц (Минск), С. Л. Кабак (Минск), Н. С. Диденко, И. В. Глушко (Минск) // Клиническая медицина [Москва]. – 2024. – Т. 102, № 3. – С. 264–267. Primary adrenal insufficiency |
Due to the non-specificity of a number of clinical manifestations of Addison’s disease, the diagnosis of primary adrenal insufficiency in general therapeutic profile hospitals causes certain difficulties. The article presents a clinical case of diagnosing primary adrenal insufficiency in combination with autoimmune thyroiditis and hypogonadism as a manifestation of autoimmune polyglandular syndrome. Signs of Addison’s disease included hyperpigmentation of the skin and mucous membranes of the oral cavity, as well as low cortisol levels and an increase in adrenocorticotropic hormone(ACTH) concentration, detected in the blood serum antibodies to thyroperoxidase — a specific marker of autoimmune thyroid gland damage. A positive result of the test for autoantibodies to steroid-producing cells indicated functional ovarian insufficiency. |
| Коляда, И. Н. Анализ смертности населения Гомельской области от цереброваскулярных болезней в 2009–2019 гг. / И. Н. Коляда (Гомель), А. М. Островский (Гомель) // Вестник неврологии, психиатрии и нейрохирургии [Москва]. – 2024. – Т. 17, № 7. – С. 906–917.
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The article presents the results of the analysis of mortality of the population of Gomel region from cerebrovascular diseases in 2009-2019. During the analysed period there was registered a statistically significant decrease in the mortality rate of the population of Gomel region from cerebrovascular diseases, including among urban residents. The decrease in the mortality rate from cerebrovascular diseases of the rural population of the region for the analysed period is statistically insignificant. The lowest excess of mortality of the rural population over mortality of the urban population was observed in 2014, the highest – in 2019. The highest mortality rates from cerebrovascular diseases are observed among the urban and rural population of Khoiniki, Petrikov and Kalinkovichi districts. A statistically significant increase in mortality from cerebrovascular diseases in 2019 compared to 2018 was found in the population above working age in Khoiniki, Petrikov and Buda-Kosheliov districts of Gomel region. The highest mortality rates of the working-age population from cerebrovascular diseases were registered in Petrikov, Kalinkovichi, Khoiniki, Oktyabrsky and Svetlogorsk districts. The highest mortality rate of persons over working age was recorded in Khoiniki district of Gomel region. In the structure of causes of mortality from cerebrovascular diseases in the first place is registered cerebral infarction, in the second place – intracerebral and other intracranial hemorrhages, in the third place – other cerebrovascular diseases. Recommendations are given to reduce mortality from the described pathology in this region. |
| Разводовский, Ю. Е. Эффективность биохимических маркеров этилглюкуронида в диагностике алкогольной зависимости: гендерный аспект / Ю. Е. Разводовский (Гродно), А. В. Шуриберко (Гродно) // Наркология [Москва]. – 2024. – Т. 23, № 5. – С. 45–48.
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Purpose: To investigate the gender aspect of using hair EG concentration to diagnose alcohol dependence. Methods. The study participants were 90 alcohol-dependent men and 15 women who were undergoing inpatient detoxification course in the Grodno Regional Clinical Centre ‘Psychiatry-Narcology’. EG concentration in hair was determined by high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS). Statistical processing of data was performed using Statistica 10.0 programme for Windows (StatSoft, Inc., USA). Results. At a threshold concentration of EG in hair of 55 pg/mg in men, the sensitivity, specificity, predictive value of positive result (PCPR), predictive value of negative result (PCER) were 95%, 96%, 98%, 90%, respectively. At a threshold concentration of EG in hair of 38 pg/mg in women, the sensitivity, specificity, PCPR, PCER of the result were 93%, 92%, 83%, 67% respectively. Conclusion. The results of the study indicate high reliability of determining the concentration of EG in hair in the diagnosis of alcohol dependence. |
| Малёваная, И. А. Оценка деятельности учреждений, осуществляющих медицинское обеспечение спортивной подготовки в Республике Беларусь / И. А. Малёваная (Минск), И. Н. Мороз (Минск) // Бюллетень Национального научно-исследовательского института общественного здоровья им. Н. А. Семашко [Москва]. – 2024. – № 3. – С. 40–48.
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The article analyses the activity of institutions providing medical support for sports training. The article characterises the scope and areas of work of a sports medicine doctor depending on the level of medical support of sports training. The necessity of organising a multilevel system of medical support of sports training is substantiated. |